Phenotypes Associated with This Genotype

Genotype
MGI:3630186

• Allelic Composition: H2^b/H2^d
• Genetic Background: (C57BL/6 x DBA/2)F1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal T cell differentiation ( J:106141 )

• after malarial infection, large populations of B220+CD3+ cells which are extrathymic T cells (CD3+) carrying a B cell marker (B220+) appear in the livers; this is not seen in the spleens of any mice after infection

• there is an increase of 40% of gamma,delta T cells in DBA/2 mice during infection; most of these are CD4-CD8-

abnormal cytokine secretion ( J:106141 )

• levels of Ifng and Il4 are lower than in B6 mice with malarial infection

increased autoantibody level ( J:106141 )

• level of IgM autoantibody is increase to a greater extent than in B6 mice

decreased susceptibility to parasitic infection ( J:106141 )

• recovery from malaria is similar to DBA/2 mice, faster than in B6 mice

hematopoietic system

abnormal T cell differentiation ( J:106141 )

• after malarial infection, large populations of B220+CD3+ cells which are extrathymic T cells (CD3+) carrying a B cell marker (B220+) appear in the livers; this is not seen in the spleens of any mice after infection

• there is an increase of 40% of gamma,delta T cells in DBA/2 mice during infection; most of these are CD4-CD8-

decreased hematocrit ( J:106141 )

• decrease in hematocrit is less than in infected C57BL/6 mice

liver/biliary system

abnormal liver physiology ( J:106141 )

• liver injury as estimated by GPT serum levels is lower than in infected B6 mice