Phenotypes Associated with This Genotype

Genotype
MGI:3629890

• Allelic Composition: Gpc3^tm1Arge/Gpc3^tm1Arge; Igf1r^tm1Arge/Igf1r^tm1Arge
• Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:75054 )

♀ • mutants are stillborn

limbs/digits/tail

abnormal calcaneum morphology ( J:75054 )

♀ • the calcaneus is not positioned at an angle with respect to the tibia resulting in a club foot like phenotype

abnormal hindlimb morphology ( J:75054 )

♀ • 9 of 14 exhibit a hindlimb defect resembling club foot; the hind paws are abnormally bent medially with respect to the axis of the tibia

skeleton

abnormal calcaneum morphology ( J:75054 )

♀ • the calcaneus is not positioned at an angle with respect to the tibia resulting in a club foot like phenotype