Phenotypes for Igf1 Igf1r MGI:3629674 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Igf1^tm1Arge/Igf1^tm1Arge Igf1r^tm1Arge/Igf1r^tm1Arge
Genetic Background	either: (involves: 129S/SvEv) or (involves: 129S/SvEv * C57BL/6J) or (involves: 129S/SvEv * MF1)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf1r^tm1Arge mutation (0 available); any Igf1r mutation (86 available)
Igf1^tm1Arge mutation (2 available); any Igf1 mutation (25 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:15108 )

• die immediately after birth of respiratory failure

growth/size/body

decreased birth weight ( J:15108 )

• birth weight is about 45% of wild-type

respiratory system

respiratory failure ( J:15108 )

skeleton

delayed bone ossification ( J:15108 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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