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Phenotypes Associated with This Genotype
Genotype
MGI:3629599
Allelic
Composition		 Tnftm2.1Gkl/Tnftm2.1Gkl
Tg(Lck-cre)I57Jxm/0
Genetic
Background		 involves: 129S/SvEv * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Lck-cre)I57Jxm mutation (5 available)
Tnftm2.1Gkl mutation (1 available); any Tnf mutation (48 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
small intestinal inflammation ( J:108572 )
• mice develop mice develop inflammatory bowel disease past 5 months of age with reduced severity compared to Tnftm2.1Gkl, Lyzstm1(cre)Ifo double homozygotes or Tnftm2Gkl heterozygotes

digestive/alimentary system
small intestinal inflammation ( J:108572 )
• mice develop mice develop inflammatory bowel disease past 5 months of age with reduced severity compared to Tnftm2.1Gkl, Lyzstm1(cre)Ifo double homozygotes or Tnftm2Gkl heterozygotes

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/28/2026
MGI 6.24 		The Jackson Laboratory