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Phenotypes Associated with This Genotype
Genotype
MGI:3629233
Allelic
Composition
Tg(ITGAM-cre)2781Gkl/0
Tg(SOD1*G37R)1Dwc/0
Genetic
Background
involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(ITGAM-cre)2781Gkl mutation (1 available)
Tg(SOD1*G37R)1Dwc mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• expression of Cre in microglia extends the lifespan of mutant SOD1-expressing mice by an average of 99 days compared to non-ITGAM-cre expressing mice

nervous system
• progression of later stage disease is slowed by an average of 75 days in mice expressing both transgenes

Mouse Models of Human Disease
OMIM ID Ref(s)
Amyotrophic Lateral Sclerosis 1; ALS1 105400 J:109131


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory