Phenotypes Associated with This Genotype

Genotype
MGI:3629231

• Allelic Composition: Tg(SOD1*G37R)1Dwc/0
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:109131 )

• transgenic mice develop end-stage disease by 8.5-11 months of age

growth/size/body

weight loss ( J:109131 )

• mice display weight loss from denervation induced muscle atrophy

nervous system

decreased motor neuron number ( J:109131 )

• mice in end-stage disease display 55% spinal motor neuron death

motor neuron degeneration ( J:109131 )

• mice develop fatal progressive motorneuron disease