Phenotypes Associated with This Genotype

Genotype
MGI:3629204

• Allelic Composition: Trp53bp2^tm1Xlu/Trp53bp2⁺
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased tumor incidence ( J:108701 )

• incidence of tumors (12/20) is much higher in heterozygous mice than in wild-type mice (4/18) over a 3 year period

increased rhabdomyosarcoma incidence ( J:108701 )

• 1/20 spontaneously developed this sarcoma: only observed in irradiated heterozygous mice, not in wild-type

increased lymphoma incidence ( J:108701 )

• 40% of mice develop lymphomas; in wild-type this is the only type of tumor occurring tumor origin is determined to be T and B cell-derived

increased T cell derived lymphoma incidence ( J:108701 )

• T cell lymphomas in various tissues are observed in both irradiated heterozygous and wild-type mice

increased squamous cell carcinoma incidence ( J:108701 )

• 1/20 showed squamous cell carcinoma

increased hemangiosarcoma incidence ( J:108701 )

• 2/20 heterozygotes developed angiosarcoma

increased incidence of tumors by ionizing radiation induction ( J:108701 )

• more irradiated heterozygotes (9/19) develop tumors than untreated heterozygotes (1/19) or irradiated wild-type mice (3/19)

muscle

increased rhabdomyosarcoma incidence ( J:108701 )

• 1/20 spontaneously developed this sarcoma: only observed in irradiated heterozygous mice, not in wild-type

endocrine/exocrine glands

increased T cell derived lymphoma incidence ( J:108701 )

• T cell lymphomas in various tissues are observed in both irradiated heterozygous and wild-type mice

hematopoietic system

increased T cell derived lymphoma incidence ( J:108701 )

• T cell lymphomas in various tissues are observed in both irradiated heterozygous and wild-type mice

immune system

increased T cell derived lymphoma incidence ( J:108701 )

• T cell lymphomas in various tissues are observed in both irradiated heterozygous and wild-type mice