Phenotypes Associated with This Genotype

Genotype
MGI:3628955

• Allelic Composition: Nrgn^tm1Sut/Nrgn^tm1Sut
• Genetic Background: involves: 129S4/SvJae * Black Swiss

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal excitatory postsynaptic potential ( J:109224 )

• presynaptic fiber volleys are significantly larger in knockout mice; normalized mean population excitatory postsynaptic potentials are smaller in knockouts than in controls

enhanced long-term potentiation ( J:109224 )

• in hippocampal slices from knockout mice, enhanced LTP is observed; at 60 minutes, LTP is larger than in controls

increased post-tetanic potentiation ( J:109224 )

• in slices from knockout mice, larger short-term post-tetanic potientiation is seen

abnormal long-term depression ( J:109224 )

• low frequency stimulation elicits a short-lasting depression followed by a slow but significant potentiation in slices from knockouts, in contrast to wild-type slices where long term depression is induced

• no frequency of stimulation could induce LTD in knockout mice