Analysis Tools
mortality/aging
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• most die within 1 day of birth
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nervous system
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• at E16.5 the number of proliferating cells is decreased in the subventricular zone and at E18.5 no BrdU labelled cells are seen in the glomerular layer suggesting that migration of interneurons into the glomerular layer is impaired
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• olfactory axons pass through the lamina cribosa by E12.5 but never reach the olfactory bulb and instead form a fibrocellular mass outside the olfactory bulb
• however, expression analysis indicates that differentiation of olfactory neurons is not significantly different from wild-type
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• olfactory axons pass through the lamina cribosa by E12.5 but never reach the olfactory bulb and instead form a fibrocellular mass outside the olfactory bulb
• at E16.5 the number of proliferating cells is decreased in the subventricular zone and at E18.5 no BrdU labelled cells are seen in the glomerular layer suggesting that migration of interneurons into the glomerular layer is impaired
• at E18.5 the olfactory sensory nerve layer (ONL) is absent and ensheathing cells normally found in the ONL are detected in the fibrocellular mass
• at E18.5, the mitral cell layer, now the outer most layer, is thicker than normal and the polarity of the mitral cells is disorganized
• at E18.5, the glomerular layer fails to form and cells expressing of Dlx1, Gad67, and Th are disorganized
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• at E15.5 and E18.5 the rostral migratory stream is shorter and wider with a disorganized anterior tip also present at E18.5
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• seen at E18.5 and P0; however telencephalon and diencephalon morphology are similar to wild-type
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• at E16.5 the number of proliferating cells is decreased in the subventricular zone
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cellular
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• at E16.5 the number of proliferating cells is decreased in the subventricular zone and at E18.5 no BrdU labelled cells are seen in the glomerular layer suggesting that migration of interneurons into the glomerular layer is impaired
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craniofacial
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• olfactory axons pass through the lamina cribosa by E12.5 but never reach the olfactory bulb and instead form a fibrocellular mass outside the olfactory bulb
• however, expression analysis indicates that differentiation of olfactory neurons is not significantly different from wild-type
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respiratory system
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• olfactory axons pass through the lamina cribosa by E12.5 but never reach the olfactory bulb and instead form a fibrocellular mass outside the olfactory bulb
• however, expression analysis indicates that differentiation of olfactory neurons is not significantly different from wild-type
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taste/olfaction
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• olfactory axons pass through the lamina cribosa by E12.5 but never reach the olfactory bulb and instead form a fibrocellular mass outside the olfactory bulb
• however, expression analysis indicates that differentiation of olfactory neurons is not significantly different from wild-type
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growth/size/body
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• olfactory axons pass through the lamina cribosa by E12.5 but never reach the olfactory bulb and instead form a fibrocellular mass outside the olfactory bulb
• however, expression analysis indicates that differentiation of olfactory neurons is not significantly different from wild-type
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