Phenotypes Associated with This Genotype

Genotype
MGI:3628920

• Allelic Composition: Kcnmb1^tm1Rwa/Kcnmb1^tm1Rwa
• Genetic Background: involves: 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

increased heart weight ( J:65415 )

• heart enlargement caused by uncomplicated essential hypertension

• larger heart-to-body weight ratios

increased systemic arterial blood pressure ( J:65415 )

• an increase in mean blood pressure over the pure 129svj mice

abnormal vasoconstriction ( J:65415 )

• cerebral arteries are significantly constricted at a given pressure, indicating an elevation in arterial tone

• the BK channels from mutant arterial smooth muscle are unable to contribute to the regulation of arterial tone

renal/urinary system

abnormal renal glomerular filtration rate ( J:83901 )

• glomerular filtration rate and fractional K+ excretion were significantly impaired in mutant mice in response to acute volume expansion

• no differences in renal function were found under euvolemic conditions

• mutant mice exhibited enhanced Na+ excretion and fractional Na+ excretion in response to acute volume expansion

hearing/vestibular/ear

hearing/vestibular/ear phenotype ( J:92443 )

N • mutant mice shows normal hearing function and cochlear structure

muscle

abnormal muscle contractility ( J:106302 )

• urinary bladder smooth muscle strips from mutant mice had elevated phasic contraction amplitude and decreased frequency when compared to control

abnormal vasoconstriction ( J:65415 )

• cerebral arteries are significantly constricted at a given pressure, indicating an elevation in arterial tone

• the BK channels from mutant arterial smooth muscle are unable to contribute to the regulation of arterial tone

growth/size/body

increased heart weight ( J:65415 )

• larger heart-to-body weight ratios

• heart enlargement caused by uncomplicated essential hypertension