Mouse Genome Informatics
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    G6pdxa-m1Neu/G6pdxa-m1Neu
involves: 102/El * C3H/El * T-stock
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
cardiovascular system
• exhibit increased susceptibility to ischemia-reperfusion injury; on reperfusion, cardiac relaxation and contractile performance are impaired as shown by elevated end-diastolic pressures and decreased percent recovery of developed pressure relative to wild type (J:102347)
• with ischemia-reperfusion, hearts exhibit increased susceptibility to cellular thiol depletion and redox imbalance relative to wild-type (J:102347)

hematopoietic system
N
• although homozygotes only have 15% G6pdx remaining activity in the blood, observe no differences in hematocrit values, red blood-cell counts, hemoglobin content, in the osmotic-fragility of red blood cells, in plasma glucose concentration, in glucose consumption in blood, or in body weight and exhibit no chronic hemolysis under normal conditions (J:58685)

homeostasis/metabolism
• exhibit increased susceptibility to ischemia-reperfusion injury; on reperfusion, cardiac relaxation and contractile performance are impaired as shown by elevated end-diastolic pressures and decreased percent recovery of developed pressure relative to wild type (J:102347)
• with ischemia-reperfusion, hearts exhibit increased susceptibility to cellular thiol depletion and redox imbalance relative to wild-type (J:102347)