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Phenotypes Associated with This Genotype
Genotype
MGI:3628915
Allelic
Composition
G6pdxa-m1Neu/G6pdxa-m1Neu
Genetic
Background
involves: 102/El * C3H/El * T-stock
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
G6pdxa-m1Neu mutation (2 available); any G6pdx mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• exhibit increased susceptibility to ischemia-reperfusion injury; on reperfusion, cardiac relaxation and contractile performance are impaired as shown by elevated end-diastolic pressures and decreased percent recovery of developed pressure relative to wild type
• with ischemia-reperfusion, hearts exhibit increased susceptibility to cellular thiol depletion and redox imbalance relative to wild-type

hematopoietic system
N
• although homozygotes only have 15% G6pdx remaining activity in the blood, observe no differences in hematocrit values, red blood-cell counts, hemoglobin content, in the osmotic-fragility of red blood cells, in plasma glucose concentration, in glucose consumption in blood, or in body weight and exhibit no chronic hemolysis under normal conditions

homeostasis/metabolism
• exhibit increased susceptibility to ischemia-reperfusion injury; on reperfusion, cardiac relaxation and contractile performance are impaired as shown by elevated end-diastolic pressures and decreased percent recovery of developed pressure relative to wild type
• with ischemia-reperfusion, hearts exhibit increased susceptibility to cellular thiol depletion and redox imbalance relative to wild-type


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory