Analysis Tools
cardiovascular system
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• exhibit increased susceptibility to ischemia-reperfusion injury; on reperfusion, cardiac relaxation and contractile performance are impaired as shown by elevated end-diastolic pressures and decreased percent recovery of developed pressure relative to wild type
• with ischemia-reperfusion, hearts exhibit increased susceptibility to cellular thiol depletion and redox imbalance relative to wild-type
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hematopoietic system
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N |
• although homozygotes only have 15% G6pdx remaining activity in the blood, observe no differences in hematocrit values, red blood-cell counts, hemoglobin content, in the osmotic-fragility of red blood cells, in plasma glucose concentration, in glucose consumption in blood, or in body weight and exhibit no chronic hemolysis under normal conditions
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homeostasis/metabolism
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• exhibit increased susceptibility to ischemia-reperfusion injury; on reperfusion, cardiac relaxation and contractile performance are impaired as shown by elevated end-diastolic pressures and decreased percent recovery of developed pressure relative to wild type
• with ischemia-reperfusion, hearts exhibit increased susceptibility to cellular thiol depletion and redox imbalance relative to wild-type
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