Mouse Genome Informatics
ht
    Dnmt3btm1Enl/Dnmt3btm6Enl
involves: 129S4/SvJae * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
• normal numbers of pups are born but most die within 24 hours

immune system
• at P1, many thymocytes are dead or dying

growth/size
• at birth, mutants are less than 2/3 the weight of normal littermates

hematopoietic system
• at P1, many thymocytes are dead or dying

cellular
• at P1, many thymocytes are dead or dying

endocrine/exocrine glands
• at P1, many thymocytes are dead or dying

Mouse Models of Human Disease
OMIM IDRef(s)
Immunodeficiency-Centromeric Instability-Facial Anomalies Syndrome 1; ICF1 242860 J:106540