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Phenotypes Associated with This Genotype
Genotype
MGI:3628828
Allelic
Composition
Dnmt3btm6Enl/Dnmt3btm7Enl
Genetic
Background
involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dnmt3btm6Enl mutation (0 available); any Dnmt3b mutation (28 available)
Dnmt3btm7Enl mutation (0 available); any Dnmt3b mutation (28 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• normal numbers of pups are born but most die within 24 hours
• almost no (only 1) homozygous mice survive to weaning

growth/size/body
• at birth, mutants are less than 2/3 the weight of normal littermates

craniofacial
• skeletons of newborn mutants show similar defect to that seen in adult Dnmt3btm7Enl mutants

skeleton
• skeletons of newborn mutants show similar defect to that seen in adult Dnmt3btm7Enl mutants

immune system
• at P1, many thymocytes are dead or dying

hematopoietic system
• at P1, many thymocytes are dead or dying

cellular
• at P1, many thymocytes are dead or dying

endocrine/exocrine glands
• at P1, many thymocytes are dead or dying


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory