Mouse Genome Informatics
ht
    Engtm1Mle/Eng+
129P2/OlaHsd-Engtm1Mle
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       

Engtm1Mle/Eng+ mice have nosebleeds and telangiectases characteristic of heriditary hemorrhagic telangiectasia

mortality/aging
• a female died at 7 weeks

cardiovascular system
• 3 of 10 have nosebleeds when observed for over a period of 7 months and some show tail bleeding
• 5 of 10 show visible telangiectases on the ears; exhibit large dilated vessels at the periphery of the ear lobe
• these small vascular lesions last for 2-3 days and then rapture and bleed, often leading to partial ear necrosis
• seen in some heterozygotes

muscle
• 5 of 10 show visible telangiectases on the ears; exhibit large dilated vessels at the periphery of the ear lobe
• these small vascular lesions last for 2-3 days and then rapture and bleed, often leading to partial ear necrosis
• seen in some heterozygotes

Mouse Models of Human Disease
OMIM IDRef(s)
Telangiectasia, Hereditary Hemorrhagic, of Rendu, Osler, and Weber; 187300 J:58502