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Phenotypes Associated with This Genotype
Genotype
MGI:3628821
Allelic
Composition
Engtm1Mle/Eng+
Genetic
Background
129P2/OlaHsd-Engtm1Mle
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Engtm1Mle mutation (0 available); any Eng mutation (27 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Engtm1Mle/Eng+ mice have nosebleeds and telangiectases characteristic of heriditary hemorrhagic telangiectasia

mortality/aging
• a female died at 7 weeks

cardiovascular system
• 3 of 10 have nosebleeds when observed for over a period of 7 months and some show tail bleeding
• 5 of 10 show visible telangiectases on the ears; exhibit large dilated vessels at the periphery of the ear lobe
• these small vascular lesions last for 2-3 days and then rapture and bleed, often leading to partial ear necrosis
• seen in some heterozygotes

muscle
• 5 of 10 show visible telangiectases on the ears; exhibit large dilated vessels at the periphery of the ear lobe
• these small vascular lesions last for 2-3 days and then rapture and bleed, often leading to partial ear necrosis
• seen in some heterozygotes


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory