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Phenotypes Associated with This Genotype
Genotype
MGI:3628806
Allelic
Composition
Shox2tm1Ddu/Shox2tm1.1Ddu
Tg(Prrx1-cre)1Cjt/0
Genetic
Background
involves: 129S2/SvPas * C57BL/6J * SJL/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Shox2tm1.1Ddu mutation (0 available); any Shox2 mutation (12 available)
Shox2tm1Ddu mutation (1 available); any Shox2 mutation (12 available)
Tg(Prrx1-cre)1Cjt mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Limb phenotype of Shox2tm1Ddu/Shox2tm1.1Ddu Tg(Prrx1-cre)1Cjt mice

mortality/aging
N
• provided adequate access to food and water homozygotes are viable

limbs/digits/tail
• development of the forelimb stylopod elements is severely impaired; however development of the forelimb zeugopd elements is similar to wild-type mice
• development of the hindlimb stylopod elements is severely impaired
• the hindlimb zeugopod is also shorter
• virtually absent at birth with only a small abnormal dorsal piece remaining that does not span the axis of the limb
• virtually absent at birth with only a tiny cartilage analage which lacks ossification is seen; in adults ossification is seen but little bone growth occurs
• markedly bowed

skeleton
• virtually absent at birth with only a small abnormal dorsal piece remaining that does not span the axis of the limb
• virtually absent at birth with only a tiny cartilage analage which lacks ossification is seen; in adults ossification is seen but little bone growth occurs
• markedly bowed
• hypertrophic chondrocytes eventually appear in the humerus but are in abnormal asymmetric locations blocking formation of the growth plate
• at E12.5, the humerus and femur cartilages are already significantly shorter (by about 50%) than in wild-type
• by E14.5 the humerus and femur cartilage malformation is as severe as in newborns
• chondrocyte differentiation in the humerus is impaired with markers for immature cells (Col2a1) still present at E18.5 and expression of later markers greatly decreased or absent


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory