Phenotypes Associated with This Genotype

Genotype
MGI:3628770

• Allelic Composition: Prkra^tm1Gcs/Prkra^tm1Gcs
• Genetic Background: either: B6.Cg-Prkra^tm1Gcs or (involves: C57BL/6)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

External and internal ear abnormalities in Prkra^tm1Gcs/Prkra^tm1Gcs mice

hearing/vestibular/ear

abnormal outer ear morphology ( J:108297 )

abnormal external auditory canal morphology ( J:108297 )

• smaller than in wild-type

small ears ( J:108297 )

abnormal middle ear morphology ( J:108297 )

• very small middle ear space and bulla; however the morphology of the cochlea is similar to wild-type

abnormal middle ear ossicle morphology ( J:108297 )

increased or absent threshold for auditory brainstem response ( J:108297 )

• thresholds are elevated by 30 - 45 dB across frequencies from 4 to 60 kHz

growth/size/body

turbinate hypoplasia ( J:108297 )

round snout ( J:108297 )

• the rostrum is rounded

short snout ( J:108297 )

abnormal outer ear morphology ( J:108297 )

abnormal external auditory canal morphology ( J:108297 )

• smaller than in wild-type

small ears ( J:108297 )

decreased body size ( J:108297 )

• easily noticeable by 4 - 6 weeks of age, not as obvious in younger mice

decreased body weight ( J:108297 )

• from 4 - 6 weeks of age onward mice weigh about 40% less than wild-type mice

craniofacial

turbinate hypoplasia ( J:108297 )

abnormal middle ear ossicle morphology ( J:108297 )

round snout ( J:108297 )

• the rostrum is rounded

short snout ( J:108297 )

abnormal outer ear morphology ( J:108297 )

abnormal external auditory canal morphology ( J:108297 )

• smaller than in wild-type

small ears ( J:108297 )

respiratory system

turbinate hypoplasia ( J:108297 )

skeleton

turbinate hypoplasia ( J:108297 )

abnormal middle ear ossicle morphology ( J:108297 )