Phenotypes Associated with This Genotype

Genotype
MGI:3628652

• Allelic Composition: Gjd3^tm1.2Kwi/Gjd3^tm1.2Kwi
• Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal impulse conducting system conduction ( J:108288 )

abnormal atrioventricular node conduction ( J:108288 )

• exhibit significantly shorter AV intervals indicating accelerated AV-nodal conduction velocity

• show significantly reduced AH durations but normal HV intervals, indicating increased supraHisian conductivity

• exhibit a significantly lower Wenckebach periodicity indicating facilitiated AV-nodal conduction

• during catheter positioning, mutants frequently exhibit AV-nodal conduction blocks

• ventricular heart rate during induced episodes of atrial fibrillation is significantly higher in the mutants than in controls due to faster AV-nodal conduction, however heart rates at rest are normal

shortened PQ interval ( J:108288 )

• PQ interval is about 25% shorter than in wild-type, however exhibit no differences in P wave, QRS width, or QT interval