Phenotypes Associated with This Genotype

Genotype
MGI:3628460

• Allelic Composition: Gja1^tm1Kdr/Gja1⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal coronary artery morphology ( J:112454 )

• 22 of 25 show various defects in patterning of the coronary arteries, including abnormal origin and course of the main coronary artery stems, multiple accessory coronary arteries, and dual septal-conal branches

abnormal impulse conducting system conduction ( J:39599 )

• in neonatal heterozygotes, ventricular epicardial conduction of paced beats is 30% slower than in wild-type neonates

• in adult (6-9 mo-old) heterozygotes, ventricular epicardial conduction is 44% slower than in wild-type hearts; no differences are observed in refractory periods

• no apparent differences in wall thickness or the orientation or fiber curvature in the three muscle layers of the left ventricle are observed

prolonged QRS complex duration ( J:39599 )

• standard 3-lead surface ECGs from adult heterozygotes indicate a significantly prolonged QRS interval relative to wild-type mice (13.41.8 ms vs 11.51.4 ms, respectively)

• no differences are observed in spontaneous heart rates either during isolated heart studies in vitro or by electrocardiography

• no differences are noted in atrioventricular conduction times in isolated neonatal heterozygous hearts, or in PQ intervals in adult ECG studies

• whole-cell recordings display no differences in any action potential parameters in ventricular myocytes isolated from neonatal heterozygous and wild-type mice