Phenotypes Associated with This Genotype

Genotype
MGI:3628455

• Allelic Composition: Ret^tm1Cti/Ret⁺
• Genetic Background: involves: 129S/SvEv * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal enteric neuron morphology ( J:107335 )

• male heterozygotes have a lower number of enteric neurons in the stomach, duodenum, jejunum, ileum, cecum and in colon; female heterozygotes display the same features in the duodenum, ileum, cecum and in both the proximal and distal part of the colon

digestive/alimentary system

abnormal large intestine morphology ( J:107335 )

• in both male and female heterozygotes, the muscular layer of proximal and distal colon is thinner than in wild-type; in females the apex of the cecum shows reduced muscle thickness, while males show a thinner muscular layer in the body and apex of the cecum

abnormal small intestine morphology ( J:107335 )

• a reduced thickness of the muscular layer of the duodenum of heterozygotes is apparent; female heterozygotes display reduced muscle thickness in the jejunum