Phenotypes Associated with This Genotype

Genotype
MGI:3626325

• Allelic Composition: Meg3^{Gt(pGTi)216Gos}/Meg3⁺
• Genetic Background: involves: 129S2/SvPas * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality ( J:30839 )

• Background Sensitivity: found in reduced numbers on a predominantly 129 background (greater than 75%)

growth/size/body

decreased body size ( J:30839 )

• considerably smaller than controls at birth and postnatally

• near normal in adulthood

• dwarfism less pronounced when transmitted maternally

• size variability when heterozygotes the progeny of two heterozygous parents

• Background Sensitivity: on a predominantly 129 background, dwarfism considerably reduced in the offspring of males who received the allele maternally

decreased body weight ( J:30839 )

• weight about 60% of controls postnatally

• near normal weight attained in adulthood

fetal growth retardation ( J:30839 )

• weight reduction detectable at E16.5

cellular

abnormal imprinting ( J:108133 )

• paternal transmission results in down regulation of Dlk1, Dio3, and Rtl1 but not Gtl2, Rian, and Mirg

• maternal transmission results in mild down regulation of Gtl2, Rian, and Mirg and no effect at all on Dlk1, Dio3, and Rtl1