Phenotypes Associated with This Genotype

Genotype
MGI:3626323

• Allelic Composition: Meg3^{Gt(pGTi)216Gos}/Meg3⁺
• Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, incomplete penetrance ( J:125994 )

• Background Sensitivity: when the allele is inherited paternally, mice exhibit neonatal lethality with smaller than normal surviving mice weighing 54% of wild-type on a predominantly 129 background

• however, when the allele is inherited maternally or paternally from a cross to a C57BL/6 female mice exhibit no increased lethality or reduced weight compared to wild-type mice

postnatal lethality ( J:125994 )

• Background Sensitivity: when the allele is inherited paternally, postnatal lethality is 29% on a predominantly 129 background

• however, when the allele is inherited maternally or paternally from a cross to a C57BL/6 female mice exhibit no increased lethality or reduced weight compared to wild-type mice

growth/size/body

decreased body size ( J:30839 )

• considerably smaller than controls at birth and postnatally

• near normal in adulthood

• dwarfism less pronounced when transmitted maternally

• size variability when heterozygotes the progeny of two heterozygous parents

• Background Sensitivity: size phenotype is always apparent on a predominantly C57BL/6 and BALB/c background

decreased body weight ( J:30839 )

• weight about 60% of controls postnatally

• near normal weight attained in adulthood

disproportionate dwarf ( J:125994 )

• however, when the allele is inherited maternally or paternally from a cross to a C57BL/6 female mice exhibit no increased lethality or reduced weight compared to wild-type mice

• Background Sensitivity: mice are dwarfed when produced from 129 females but not when produced from C57BL/6 females

• however, successive mating to 129 mice reduced and extinguished the dwarfism phenotype

fetal growth retardation ( J:30839 )

• weight reduction detectable at E16.5

cellular

abnormal imprinting ( J:108133 , J:125994 )

• paternal transmission results in down regulation of Dlk1, Dio3, and Rtl1 but not Gtl2, Rian, and Mirg (J:108133)

• maternal transmission results in mild down regulation of Gtl2, Rian, and Mirg and no effect at all on Dlk1, Dio3, and Rtl1 (J:108133)

• imprinting and expression of Dlk1 and Gtl2 is altered depending of the parent of origin of the allele (paternal results in loss of Gtl2 imprinting while maternal results in lose of Dlk1 imprinting) (J:125994)

maternal imprinting ( J:125994 )