Phenotypes Associated with This Genotype

Genotype
MGI:3626256

• Allelic Composition: Lcp2^tm1Gak/Lcp2^tm1Gak
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, incomplete penetrance ( J:91369 )

• there is a selective loss of homozygous progeny observed

hematopoietic system

abnormal platelet activation ( J:162815 )

• platelets fail to activate in response to plating on lymphatic microvascular endothelial cells (LEC) unlike wild-type cells

• platelets from neonates without vascular phenotypes exhibit low levels of convulxin-stimulated fibrinogen binding compared with similarly treated wild-type cells

decreased platelet aggregation ( J:162815 )

• platelets fail to form aggregates on microvascular endothelial cells (LEC) under flow unlike similarly treated wild-type cells

homeostasis/metabolism

abnormal platelet activation ( J:162815 )

• platelets fail to activate in response to plating on lymphatic microvascular endothelial cells (LEC) unlike wild-type cells

• platelets from neonates without vascular phenotypes exhibit low levels of convulxin-stimulated fibrinogen binding compared with similarly treated wild-type cells

decreased platelet aggregation ( J:162815 )

• platelets fail to form aggregates on microvascular endothelial cells (LEC) under flow unlike similarly treated wild-type cells