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Phenotypes Associated with This Genotype
Genotype
MGI:3625927
Allelic
Composition		 Sox2tm2Lpev/Sox2tm2Lpev
Tg(Pax6-cre,GFP)2Pgr/?
Genetic
Background		 involves: 129S/SvEv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox2tm2Lpev mutation (1 available); any Sox2 mutation (56 available)
Tg(Pax6-cre,GFP)2Pgr mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
abnormal retina progenitor cell morphology ( J:108452 )
• the loss of general retinal progenitor cell characteristics as determined by retinal differentiation makers
abnormal eye size ( J:108452 )
• retinas are significantly smaller in size compared with Sox2tm2Lpev/Sox2+ with a transgene control note: marked reduction of cell proliferation in the distal retina by E13.5

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory