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Phenotypes Associated with This Genotype
Genotype
MGI:3625853
Allelic
Composition		 Acvr1btm1Enl/Acvr1b+
Gdf1tm1Sjl/Gdf1+
Nodaltm1Rob/Nodal+
Genetic
Background		 involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Acvr1btm1Enl mutation (0 available); any Acvr1b mutation (37 available)
Gdf1tm1Sjl mutation (1 available); any Gdf1 mutation (8 available)
Nodaltm1Rob mutation (2 available); any Nodal mutation (41 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal forebrain morphology ( J:108723 )
• 3 of 19 mutants have a single forebrain vesicle

respiratory system
abnormal nasal septum morphology ( J:108723 )
• 3 of 19 mutants have a fused nasal cavity

craniofacial
abnormal nasal septum morphology ( J:108723 )
• 3 of 19 mutants have a fused nasal cavity

growth/size/body
abnormal nasal septum morphology ( J:108723 )
• 3 of 19 mutants have a fused nasal cavity

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/20/2026
MGI 6.24 		The Jackson Laboratory