Phenotypes Associated with This Genotype

Genotype
MGI:3625841

• Allelic Composition: Kcnj6^wv/Kcnj6^wv
• Genetic Background: involves: C57BL/6J * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal hippocampal mossy fiber innervation pattern ( J:30108 )

• mossy fibers emanating from the hilus of the dentate gyrus are not confined to the layers flanking the pyramidal cell layer

abnormal hippocampus pyramidal cell layer ( J:30108 )

• in homozygous mutants the pyramidal cell layer of area CA3 appears to be thicker than normal

• subdivision of the pyramidal layer into 2 and 3 layers is seen in area CA3

ectopic hippocampus pyramidal cells ( J:30108 )

• ectopic pyramidal cells are seen in the stratum radiatum and/or in the stratum oriens: these appear as small clusters or single cells surrounded by neuropil