Phenotypes Associated with This Genotype

Genotype
MGI:3625829

• Allelic Composition: Dicer1^tm1Tara/Dicer1^tm1Tara; Tg(KRT14-cre)1Efu/?
• Genetic Background: involves: 129P2/OlaHsd * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:106792 )

• began to lose weight within 1-2 day after birth, and died by day 6

• mutant mice are normal at birth and continued to feed for several days

homeostasis/metabolism

dehydration ( J:106792 )

• appeared dehydrated before death

cellular

increased apoptosis ( J:106792 )

• showed signs of apoptosis in skin as early as E17.5

• frequency of apoptosis was higher in the hair germ

• at P6.5, apoptosis is enriched in hair follicles, including abnormal cysts in the epidermis

integument

abnormal hair follicle morphology ( J:106792 )

• hair germs appear to evaginate into the epidermis

• hair germ-like cysts became prevalent, markedly distorting the overlying epidermis

abnormal vibrissa morphology ( J:106792 )

• showed malformed whiskers