Phenotypes Associated with This Genotype

Genotype
MGI:3625289

• Allelic Composition: Pycard^tm1Vmd/Pycard^tm1Vmd
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased interleukin-1 beta secretion ( J:106976 , J:124226 )

• unlike macrophages from wild-type mice, macrophages from Pycard-deficient mice do not release significant amounts of Il-1beta when primed with LPS and treated with nigericin or maitotoxin to deplete intracellular K+ (J:106976)

• following stimulation with monosodium urate (MSU) and calcium pyrophosphate dihydrate (CPPD), IL-1-beta release from peritoneal macrophages is impaired (J:124226)

decreased interleukin-18 secretion ( J:106976 )

• unlike macrophages from wild-type mice, macrophages from Pycard-deficient mice do not release significant amounts of Il-18 when primed with LPS and treated with nigericin or maitotoxin to deplete intracellular K+

abnormal response to infection ( J:106976 )

• macrophages from null mice show reduced or undetectable Il-1beta release and caspase-1 activation in culture when infected with Salmonella or Francisella and reduced or undetectable Il-18 release upon infection with Salmonella, S. aureus, Francisella or Listeria compared to wild-type macrophages