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Phenotypes Associated with This Genotype
Genotype
MGI:3625289
Allelic
Composition
Pycardtm1Vmd/Pycardtm1Vmd
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pycardtm1Vmd mutation (1 available); any Pycard mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• unlike macrophages from wild-type mice, macrophages from Pycard-deficient mice do not release significant amounts of Il-1beta when primed with LPS and treated with nigericin or maitotoxin to deplete intracellular K+ (J:106976)
• following stimulation with monosodium urate (MSU) and calcium pyrophosphate dihydrate (CPPD), IL-1-beta release from peritoneal macrophages is impaired (J:124226)
• unlike macrophages from wild-type mice, macrophages from Pycard-deficient mice do not release significant amounts of Il-18 when primed with LPS and treated with nigericin or maitotoxin to deplete intracellular K+
• macrophages from null mice show reduced or undetectable Il-1beta release and caspase-1 activation in culture when infected with Salmonella or Francisella and reduced or undetectable Il-18 release upon infection with Salmonella, S. aureus, Francisella or Listeria compared to wild-type macrophages


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory