Phenotypes Associated with This Genotype

Genotype
MGI:3625275

• Allelic Composition: Espl1^tm1.2Kna/Espl1⁺; Pttg1^tm1.2Kna/Pttg1^tm1.2Kna
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:107916 )

• die at E11.5

cellular

abnormal cell nucleus morphology ( J:107916 )

• at E9.5 larger, lobed nuclei are seen in several organs, including the somites, heart, and brain

• after 10 days in culture MEFs have large lobed nuclei

abnormal cell nucleus size ( J:107916 )

• at E9.5 larger, lobed nuclei are seen in several organs, including the somites, heart, and brain

• after 10 days in culture MEFs have large lobed nuclei

abnormal mitosis ( J:107916 )

• 16 of 24 mitotic MEF cells had multipolar spindles and 8 were undergoing anaphase with lagging chromosomes

abnormal mitotic spindle morphology ( J:107916 )

• 16 of 24 mitotic MEF cells had multipolar spindles

abnormal cell death ( J:107916 )

• extensive cell death is seen at E9.5

embryo

decreased embryo size ( J:107916 )

• at E10.5

abnormal neural tube morphology ( J:107916 )

• at E10.5

abnormal somite development ( J:107916 )

• irregular somites are seen at E10.5

nervous system

abnormal neural tube morphology ( J:107916 )

• at E10.5

growth/size/body

decreased embryo size ( J:107916 )

• at E10.5