Phenotypes Associated with This Genotype

Genotype
MGI:3625155

• Allelic Composition: Slc39a1^tm1.1Gka/Slc39a1^tm1.1Gka
• Genetic Background: involves: 129X1/SvJ * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

embryo

abnormal embryo development ( J:108627 )

• when dams are fed a zinc-deficient diet (<1 ppm Zn) from day E8, 45% of homozygous mutant embryos exhibit gross abnormalities at day E14, vs. 13.3% (this study; literature values = 13-23%) of wild-type embryos

embryonic growth retardation ( J:108627 )

• of the abnormal embryos of both mutant and wild-type zinc-deprived dams, approximately two-thirds are mildly affected (exhibiting growth retardation and delayed limb development)

• of the abnormal embryos of both mutant and wild-type zinc-deprived dams, approximately one-third are severely affected (having craniofacial defects in addition to severe retardation of both growth and development)

growth/size/body

embryonic growth retardation ( J:108627 )

• of the abnormal embryos of both mutant and wild-type zinc-deprived dams, approximately two-thirds are mildly affected (exhibiting growth retardation and delayed limb development)

• of the abnormal embryos of both mutant and wild-type zinc-deprived dams, approximately one-third are severely affected (having craniofacial defects in addition to severe retardation of both growth and development)

limbs/digits/tail

abnormal limb development ( J:108627 )

• of the abnormal embryos of both mutant and wild-type zinc-deprived dams, approximately two-thirds are mildly affected (exhibiting growth retardation and delayed limb development)

craniofacial

abnormal craniofacial development ( J:108627 )

• of the abnormal embryos of both mutant and wild-type zinc-deprived dams, approximately one-third are severely affected (having craniofacial defects in addition to severe retardation of both growth and development)