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Phenotypes Associated with This Genotype
Genotype
MGI:3625063
Allelic
Composition
Il4tm1Cgn/Il4tm1Cgn
Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0
Genetic
Background
NOD.Cg-Il4tm1Cgn Tg(TcraBDC2.5,TcrbBDC2.5)1Doi
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il4tm1Cgn mutation (6 available); any Il4 mutation (22 available)
Tg(TcraBDC2.5,TcrbBDC2.5)1Doi mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• equal degrees of insulitis are detected at 5 weeks in transgenic IL4-deficient NOD mice and control transgenic NOD mice

immune system
• equal degrees of insulitis are detected at 5 weeks in transgenic IL4-deficient NOD mice and control transgenic NOD mice
• Il4-deficient transgenic NOD mice do not show early or frequent diabetes compared to control transgenic NOD mice

Mouse Models of Human Disease
OMIM ID Ref(s)
Diabetes Mellitus, Insulin-Dependent; IDDM 222100 J:85924


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory