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Phenotypes Associated with This Genotype
Genotype
MGI:3625060
Allelic
Composition
Il4tm1Cgn/Il4tm1Cgn
Genetic
Background
either: NOD.129-Il4tm1Cgn or (involves: 129 * NOD)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il4tm1Cgn mutation (6 available); any Il4 mutation (23 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• at 12 weeks, insulitis incidence is similar in homozygous mutants and heterozygous controls on the NOD background (N4)

immune system
• at 12 weeks, insulitis incidence is similar in homozygous mutants and heterozygous controls on the NOD background (N4)
• there is no difference in timing or penetrance of diabetes in IL4-deficient NOD mice (N8) compared to heterozygous or wild-type NOD mice

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
type 1 diabetes mellitus DOID:9744 OMIM:222100
J:85924


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/07/2017
MGI 6.11
The Jackson Laboratory