Phenotypes Associated with This Genotype

Genotype
MGI:3624989

• Allelic Composition: Prdm9^tm1Ymat/Prdm9^tm1Ymat
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

abnormal ovarian folliculogenesis ( J:102875 )

♀ • at 5 weeks of age no growing follicles at any stage of development are seen

decreased testis weight ( J:102875 )

♂ • at 8 weeks of age, testis weigh 75% less than in wild-type mice

abnormal gametogenesis ( J:102875 )

decreased oocyte number ( J:102875 )

♀ • from E17.5 the number of germ cells is decreased with few present in neonates

azoospermia ( J:102875 )

♂

abnormal chromosomal synapsis ( J:102875 )

• deficient pairing of homologous chromosomes

abnormal female meiosis ( J:102875 )

♀ • meitotic arrest with impaired homologous chromosome pairing and sex body formation

♀ • pachytene chromosomes are frequently branched and connected to other chromosomes

arrest of male meiosis ( J:102875 )

♂ • meitotic arrest with impaired homologous chromosome pairing and sex body formation

♂ • pachytene chromosomes are frequently branched and connected to other chromosomes

female infertility ( J:102875 )

♀

male infertility ( J:102875 )

♂

endocrine/exocrine glands

abnormal ovarian folliculogenesis ( J:102875 )

♀ • at 5 weeks of age no growing follicles at any stage of development are seen

decreased testis weight ( J:102875 )

♂ • at 8 weeks of age, testis weigh 75% less than in wild-type mice

cellular

decreased oocyte number ( J:102875 )

♀ • from E17.5 the number of germ cells is decreased with few present in neonates

azoospermia ( J:102875 )

♂

abnormal double-strand DNA break repair ( J:102875 )

• germ cells show impaired double strand break repair compared to wild-type

homeostasis/metabolism

abnormal double-strand DNA break repair ( J:102875 )

• germ cells show impaired double strand break repair compared to wild-type