Phenotypes Associated with This Genotype

Genotype
MGI:3624970

• Allelic Composition: X/Yaa
• Genetic Background: involves: BXSB * NZB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:6235 )

♂ • mean longevity for males is 352 +/- 35 days while males with a wild-type Yaa allele survive 2.5 times longer

immune system

enlarged lymph nodes ( J:6235 )

♂ • moderately enlarged

♂ • at 18 to 25 weeks the combined weight of the axillary, mesenteric, and renal lymph nodes is increased 5-fold compared to C57BL/6J males

increased susceptibility to autoimmune disorder ( J:6235 )

♂ • accelerated autoimmune syndrome relative to males with a wild-type Yaa allele