Phenotypes Associated with This Genotype

Genotype
MGI:3624943

• Allelic Composition: X/Yaa
• Genetic Background: (SJL/J x BXSB)F1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:6235 )

♂ • mean longevity for males is 308 +/- 26 days while only 8 of 16 reciprocal hybrid males died between 270 and 684 days

immune system

enlarged lymph nodes ( J:6235 )

♂ • moderately enlarged

♂ • at 18 to 25 weeks the combined weight of the axillary, mesenteric, and renal lymph nodes is increased 5-fold compared to C57BL/6J males

increased susceptibility to autoimmune disorder ( J:6235 )

♂ • accelerated autoimmune syndrome relative to reciprocal hybrid males