Mouse Genome Informatics
ht
    Mecp2tm1.1Bird/Mecp2+
involves: 129P2/OlaHsd * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
behavior/neurological
• acquire hindlimb clasping at ages greater than 3 months (J:67910)
• although heterozygous females initially show no symptoms and raise normal litters, they acquire inertia at ages greater than 3 months (J:67910)
• in an open field test, visit fewer squares, spend more time being immotile and rear less than controls, however this is not due to increased anxiety, as fecal bolus counts, grooming times and time spent in different zones of the field are similar to controls (J:67910)

respiratory system
• often exhibit breathing irregularities by 9 months of age (J:67910)

Mouse Models of Human Disease
OMIM IDRef(s)
Rett Syndrome; RTT 312750 J:67910