Mouse Genome Informatics
hm
    Mecp2tm1.1Bird/Mecp2tm1.1Bird
involves: 129P2/OlaHsd * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
• variable progression of symptoms leads to rapid weight loss and death at about 54 days of age (J:67910)

behavior/neurological
• most mutants develop hindlimb clasping after 7 weeks of age (J:67910)
• exhibit reduced spontaneous movement between 3 and 8 weeks of age (J:67910)
• develop a stiff, uncoordinated gait between 3 and 8 weeks of age (J:67910)

growth/size
• variable progression of symptoms leads to rapid weight loss and death at about 54 days of age (J:67910)

respiratory system
• most mutants exhibit irregular breathing after 3-8 weeks of age (J:67910)

craniofacial
• frequently exhibit misalignment of the jaws (J:67910)
• frequently exhibit uneven wearing of the teeth (J:67910)

skeleton
• frequently exhibit misalignment of the jaws (J:67910)

hearing/vestibular/ear
• some mutants fail to respond to sound, although neither motor defects nor sensory defects are detected (J:67910)

Mouse Models of Human Disease
OMIM IDRef(s)
Rett Syndrome; RTT 312750 J:67910