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Phenotypes Associated with This Genotype
Genotype
MGI:3624717
Allelic
Composition
Mecp2tm1.1Bird/Mecp2tm1.1Bird
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mecp2tm1.1Bird mutation (1 available); any Mecp2 mutation (25 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• variable progression of symptoms leads to rapid weight loss and death at about 54 days of age

behavior/neurological
• most mutants develop hindlimb clasping after 7 weeks of age
• exhibit reduced spontaneous movement between 3 and 8 weeks of age
• develop a stiff, uncoordinated gait between 3 and 8 weeks of age

growth/size/body
• frequently exhibit uneven wearing of the teeth
• variable progression of symptoms leads to rapid weight loss and death at about 54 days of age

respiratory system
• most mutants exhibit irregular breathing after 3-8 weeks of age

craniofacial
• frequently exhibit misalignment of the jaws
• frequently exhibit uneven wearing of the teeth

skeleton
• frequently exhibit misalignment of the jaws
• frequently exhibit uneven wearing of the teeth

hearing/vestibular/ear
• some mutants fail to respond to sound, although neither motor defects nor sensory defects are detected

Mouse Models of Human Disease
OMIM ID Ref(s)
Rett Syndrome; RTT 312750 J:67910


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory