Mouse Genome Informatics
involves: 129S4/SvJae * BALB/c * C57BL/6
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
• most die at about 10 weeks of age without obvious correlation between physical deterioration and time of death (J:67909)

• appear healthy for the first few weeks of age but develop abnormal behavior, such as nervousness, at 5 weeks of age (J:67909)
• seen at 5 weeks of age (J:67909)
• exhibit body trembling at 5 weeks of age (J:67909)
• at late stages of disease, mutants tremble when handled (J:67909)
• seen at late stages of disease (J:67909)

nervous system
• neurons in the CA2 region are 15-25% smaller than in controls at 9 weeks of age (J:67909)
• cell bodies and nuclei or neurons in sections of hippocampus, cerebral cortex, and cerebellum are smaller in size and more densely packed (J:67909)

• most exhibit signs of physical deterioration by 8 weeks of age and often begin to lose weight at late stages of disease (J:67909)
• 8 of 17 become overweight and obese at 40-60 days of age (J:67909)

• frequently display cold extremities (J:67909)

respiratory system
• occasionally show heavy breathing at 5 weeks of age (J:67909)

Mouse Models of Human Disease
Rett Syndrome; RTT 312750 J:67909