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Phenotypes Associated with This Genotype
involves: 129S4/SvJae * BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mecp2tm1.1Jae mutation (2 available); any Mecp2 mutation (27 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
• most die at about 10 weeks of age without obvious correlation between physical deterioration and time of death

• appear healthy for the first few weeks of age but develop abnormal behavior, such as nervousness, at 5 weeks of age
• seen at 5 weeks of age
• exhibit body trembling at 5 weeks of age
• at late stages of disease, mutants tremble when handled
• seen at late stages of disease

nervous system
• neurons in the CA2 region are 15-25% smaller than in controls at 9 weeks of age
• cell bodies and nuclei or neurons in sections of hippocampus, cerebral cortex, and cerebellum are smaller in size and more densely packed

• most exhibit signs of physical deterioration by 8 weeks of age and often begin to lose weight at late stages of disease
• 8 of 17 become overweight and obese at 40-60 days of age

• frequently display cold extremities

respiratory system
• occasionally show heavy breathing at 5 weeks of age

Mouse Models of Human Disease
OMIM ID Ref(s)
Rett Syndrome; RTT 312750 J:67909

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.07
The Jackson Laboratory