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Phenotypes Associated with This Genotype
Genotype
MGI:3624674
Allelic
Composition
Mecp2tm1.1Jae/Y
Genetic
Background
involves: 129S4/SvJae * BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mecp2tm1.1Jae mutation (2 available); any Mecp2 mutation (22 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• most die at about 10 weeks of age without obvious correlation between physical deterioration and time of death (J:67909)
• most die at about 10 weeks of age without obvious correlation between physical deterioration and time of death (J:67909)

behavior/neurological
• appear healthy for the first few weeks of age but develop abnormal behavior, such as nervousness, at 5 weeks of age (J:67909)
• appear healthy for the first few weeks of age but develop abnormal behavior, such as nervousness, at 5 weeks of age (J:67909)
• seen at 5 weeks of age (J:67909)
• seen at 5 weeks of age (J:67909)
• exhibit body trembling at 5 weeks of age (J:67909)
• at late stages of disease, mutants tremble when handled (J:67909)
• exhibit body trembling at 5 weeks of age (J:67909)
• at late stages of disease, mutants tremble when handled (J:67909)
• seen at late stages of disease (J:67909)
• seen at late stages of disease (J:67909)

nervous system
(J:67909)
(J:67909)
(J:67909)
(J:67909)
• neurons in the CA2 region are 15-25% smaller than in controls at 9 weeks of age (J:67909)
• neurons in the CA2 region are 15-25% smaller than in controls at 9 weeks of age (J:67909)
• cell bodies and nuclei or neurons in sections of hippocampus, cerebral cortex, and cerebellum are smaller in size and more densely packed (J:67909)
• cell bodies and nuclei or neurons in sections of hippocampus, cerebral cortex, and cerebellum are smaller in size and more densely packed (J:67909)

growth/size/body
• most exhibit signs of physical deterioration by 8 weeks of age and often begin to lose weight at late stages of disease (J:67909)
• most exhibit signs of physical deterioration by 8 weeks of age and often begin to lose weight at late stages of disease (J:67909)
• 8 of 17 become overweight and obese at 40-60 days of age (J:67909)
• 8 of 17 become overweight and obese at 40-60 days of age (J:67909)

homeostasis/metabolism
• frequently display cold extremities (J:67909)
• frequently display cold extremities (J:67909)

respiratory system
• occasionally show heavy breathing at 5 weeks of age (J:67909)
• occasionally show heavy breathing at 5 weeks of age (J:67909)

Mouse Models of Human Disease
OMIM ID Ref(s)
Rett Syndrome; RTT 312750 J:67909


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory