Mouse Genome Informatics
ht
    Mecp2tm1Hzo/Mecp2+
129S7/SvEvBrd-Mecp2tm1Hzo
Key:
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• females display milder and more variable features of Rett Syndrome than males, presumably due to differences in the pattern of X chromosome inactivation
• 62% of females exhibit tremors
• in the wire suspension test, females show normal performance at 5-6 weeks of age, but are impaired at older ages (35-39 weeks)
• females perform as well as wild-type on a thin horizontal wooden dowel, even at 35-39 weeks of age
• 69% of females display stereotypic forepaw movements (rapid and repetitive movement of the forelimbs, often bring them together)

Mouse Models of Human Disease
OMIM IDRef(s)
Rett Syndrome; RTT 312750 J:78009