Phenotypes Associated with This Genotype

Genotype
MGI:3624554

• Allelic Composition: Mecp2^tm1Hzo/Mecp2⁺
• Genetic Background: 129S7/SvEvBrd-Mecp2^tm1Hzo

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal behavior ( J:78009 )

♀ • females display milder and more variable features of Rett Syndrome than males, presumably due to differences in the pattern of X chromosome inactivation

tremors ( J:78009 )

♀ • 62% of females exhibit tremors

impaired coordination ( J:78009 )

♀ • in the wire suspension test, females show normal performance at 5-6 weeks of age, but are impaired at older ages (35-39 weeks)

♀ • females perform as well as wild-type on a thin horizontal wooden dowel, even at 35-39 weeks of age

increased stereotypic behavior ( J:78009 )

♀ • 69% of females display stereotypic forepaw movements (rapid and repetitive movement of the forelimbs, often bring them together)

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Rett syndrome		DOID:1206	OMIM:312750 OMIM:613454	J:78009