Analysis Tools
mortality/aging
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• most survive to at least one year of age, however about 10% die after 10 months of age
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behavior/neurological
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• amount of exploratory behavior in the center of the open field does not change during testing like in wild-type mice which increase activity in the center space over time, likely reflecting heightened anxiety
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• develop subtle tremors at around 6 weeks of age that worsen with age and are visibly apparent by 4 months of age
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• young mice perform well on motor function tests but become deficient as they age
• exhibit a small impairment in the ability to stay on a modified rotarod (covered with duct tape to eliminate the grips), however do not exhibit defects in forepaw grip strength
• in a vertical pole test, mutants fall off the pole more readily than wild-type
• in a wire suspension test, mutants drop earlier than wild-type
• on a thin horizontal wooden dowel, mutants rapidly lose balance and fall off the dowel
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• mutants rapidly and repetitively move their forelimbs, often bringing them together and sometimes holding them together for several seconds
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• although overall level of rearing is not significantly lower, males rear less during the last 10 min interval of testing
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• travel shorter distances and spend less time walking in the open-field test
• show normal activity during the first 10 min interval but reduced activity during the second and third 10 min time intervals
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• mutants rapidly and repetitively move their forelimbs, often bringing them together and sometimes holding them together for several seconds
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• in a tube test for social interaction, wild-type mice typically retreated when confronted with mutants, while mutants did not
• total time that wild-type intruder mice spent interacting with mutants is significantly shorter than the time spent interacting with wild-type mice
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• spontaneous behavioral myoclonic jerks and seizures are seen in some mice after 8 months of age
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nervous system
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• spontaneous behavioral myoclonic jerks and seizures are seen in some mice after 8 months of age
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cellular
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• exhibit histone H3 hyperacetylation in the cerebellum, cerebral cortex, and spleen, indicating that chromatin architecture is abnormal
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skeleton
integument
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• after 8 months of age, fur is noticeably more disheveled
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greasy coat
(
J:78009
)
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• after 8 months of age, fur is noticeably more oily
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| Rett syndrome | DOID:1206 |
OMIM:312750 OMIM:613454 |
J:78009 | |
