Phenotypes Associated with This Genotype

Genotype
MGI:3624516

• Allelic Composition: In(4)56Rk/+
• Genetic Background: involves: C57BL/6J * DBA/2J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

abnormal ocular fundus morphology ( J:41514 )

• optic atrophy appears in the fundus by 4 weeks of age

abnormal retina vasculature morphology ( J:41514 )

• retinal vessel attenuation appears in the fundus by 4 weeks of age

abnormal retina pigmentation ( J:41514 )

• pigment spots appear in the fundus by 4 weeks of age

abnormal retina outer nuclear layer morphology ( J:41514 )

• the outer nuclear layer begins to reduce at 10 days and is lost by 6 weeks of age

abnormal retina outer plexiform layer morphology ( J:41514 )

• layer begins to reduce at 10 days of age in mutants and is totally lost at 6 weeks

abnormal retina photoreceptor layer morphology ( J:41514 )

• by 2 weeks of age, the photoreceptor layer

retina photoreceptor degeneration ( J:41514 )

• by 3 weeks of age, only cones are detected in mutants; by 6 weeks, there are no photoreceptors

abnormal eye electrophysiology ( J:41514 )

• in mutants, the electroretinogram is never normal

nervous system

retina photoreceptor degeneration ( J:41514 )

• by 3 weeks of age, only cones are detected in mutants; by 6 weeks, there are no photoreceptors

pigmentation

abnormal retina pigmentation ( J:41514 )

• pigment spots appear in the fundus by 4 weeks of age

cardiovascular system

abnormal retina vasculature morphology ( J:41514 )

• retinal vessel attenuation appears in the fundus by 4 weeks of age