Analysis Tools
immune system
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• CD4+ T cells isolated from OVA-immunized mice show less proliferation in response to secondary antigen exposure than wild-type T cells
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• splenocytes from null mice have a lower proliferative response to secondary exposure to OVA than do wild-type
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• knockouts have lower levels of IgE and IgG2 than wild-type mice
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• knockouts sensitized to OVA and challenged with OVA do not show increased levels of cytokines like control mice do
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• knockout mice immunized 2x with OVA have much fewer cellular infiltrates and very little goblet cell hyperplasia in the bronchi when challenged with OVA compared wild-type controls challenged with OVA
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respiratory system
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• knockout mice immunized 2x with OVA have much fewer cellular infiltrates and very little goblet cell hyperplasia in the bronchi when challenged with OVA compared wild-type controls challenged with OVA
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hematopoietic system
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• CD4+ T cells isolated from OVA-immunized mice show less proliferation in response to secondary antigen exposure than wild-type T cells
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• splenocytes from null mice have a lower proliferative response to secondary exposure to OVA than do wild-type
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• knockouts have lower levels of IgE and IgG2 than wild-type mice
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cellular
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• CD4+ T cells isolated from OVA-immunized mice show less proliferation in response to secondary antigen exposure than wild-type T cells
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• splenocytes from null mice have a lower proliferative response to secondary exposure to OVA than do wild-type
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