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Phenotypes Associated with This Genotype
Genotype
MGI:3624431
Allelic
Composition		 Il2rgtm1Wjl/Y
Crlf2tm1Wjl/Crlf2tm1Wjl
Genetic
Background		 involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Crlf2tm1Wjl mutation (1 available); any Crlf2 mutation (24 available)
Il2rgtm1Wjl mutation (84 available); any Il2rg mutation (177 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
thymus hypoplasia ( J:108209 )
• double knockout mice have very reduced thymic cellularity; cellularity is reduced from that observed in Ilr2g single knockouts which is significantly less than that of controls

hematopoietic system
thymus hypoplasia ( J:108209 )
• double knockout mice have very reduced thymic cellularity; cellularity is reduced from that observed in Ilr2g single knockouts which is significantly less than that of controls

endocrine/exocrine glands
thymus hypoplasia ( J:108209 )
• double knockout mice have very reduced thymic cellularity; cellularity is reduced from that observed in Ilr2g single knockouts which is significantly less than that of controls

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory