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Phenotypes Associated with This Genotype
Genotype
MGI:3624430
Allelic
Composition		 Crlf2tm1Wjl/Crlf2tm1Wjl
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Crlf2tm1Wjl mutation (1 available); any Crlf2 mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal lymphopoiesis ( J:108209 )
• after sublethal irradiation, mutants do not recover thymic or splenic cellularity after 4 weeks, while controls show high recovery of cellularity after 4 weeks
decreased B cell number ( J:108209 )
• spleens of irradiated mutants have reduced numbers of B220+ CD19+ B cells compared to wild-type controls, indicating less efficient B cell recovery
decreased single-positive T cell number ( J:108209 )
• after irradiation, CD4+ and CD8+ subpopulations in the thymus and spleen are lower in mutants compared to wild-type littermates

immune system
abnormal lymphopoiesis ( J:108209 )
• after sublethal irradiation, mutants do not recover thymic or splenic cellularity after 4 weeks, while controls show high recovery of cellularity after 4 weeks
decreased B cell number ( J:108209 )
• spleens of irradiated mutants have reduced numbers of B220+ CD19+ B cells compared to wild-type controls, indicating less efficient B cell recovery
decreased single-positive T cell number ( J:108209 )
• after irradiation, CD4+ and CD8+ subpopulations in the thymus and spleen are lower in mutants compared to wild-type littermates

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory