Phenotypes Associated with This Genotype

Genotype
MGI:3624362

• Allelic Composition: Mapk3^tm1Gela/Mapk3^tm1Gela
• Genetic Background: either: 129(Cg)-Mapk3^tm1Gela or B6.129-Mapk3^tm1Gela

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal cytokine secretion ( J:107504 )

• nulls on the 129 background show increased Ag-induced production of Il17 and decreased Il5 production compared to wild-type 129 mice

increased susceptibility to experimental autoimmune encephalomyelitis ( J:107504 )

• in the MOG35-55 induced model of EAE, Mapk3-deficient mice and controls of either background show susceptibility to EAE; knockouts on the 129 background show increased susceptibility compared to 129 control mice

• inflammation is mildly increased in Erk1-deficient mice on the 129 background compared to 129 controls