Phenotypes Associated with This Genotype

Genotype
MGI:3624330

• Allelic Composition: Trp53^tm1Wahl/Trp53^tm1Wahl
• Genetic Background: involves: 129S4/SvJae

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal cell cycle ( J:64367 , J:100189 )

• MEFs do not arrest like wild-type and continue to cycle in response to gamma-irradiation or nucleotide pool depletion via PALA, an inhibitor of aspartate transcarbamylase (low G1/S ratio) (J:64367)

• embryonic fibroblasts from Trp53-deficient mice display a lack of cell cycle arrest upon exposure to increasing doses of ionizing radiation (J:100189)

decreased cellular sensitivity to gamma-irradiation ( J:64367 )

• MEFs do not arrest like wild-type and continue to cycle in response to gamma-irradiation

• less than 1% of thymocytes from irradiated mutants undergo apoptosis compared to 35-60% of wild-type thymocytes

increased fibroblast proliferation ( J:64367 )

• MEFs continue to proliferate past the point when normal MEFs undergo replicative senescence