Phenotypes Associated with This Genotype

Genotype
MGI:3624328

• Allelic Composition: Palld^tm1Zgwg/Palld^tm1Zgwg
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:100650 )

• homozygous embryos are viable until E14.5-15.5

cellular

abnormal cell adhesion ( J:100650 )

• plated embryonic fibroblasts from mutants show a decreased ability to attach to fibronectin in a palladin dose-dependent manner

decreased fibroblast cell migration ( J:100650 )

• fibroblasts from palladin-deficient mice show reduced motility compared to wild-type cells in a wound-healing assay

nervous system

open neural tube ( J:100650 )

• at E9.5, neural tube of mutants remains open from the midbrain to the hindbrain; mutants show herniation of the liver and intestine due to ventral closure defects

exencephaly ( J:100650 )

embryo

open neural tube ( J:100650 )

• at E9.5, neural tube of mutants remains open from the midbrain to the hindbrain; mutants show herniation of the liver and intestine due to ventral closure defects