Phenotypes Associated with This Genotype

Genotype
MGI:3624130

• Allelic Composition: Nck1^tm1Paw/Nck1^tm1Paw; Nck2^tm3Paw/Nck2^tm3Paw; Tg(Nphs2-cre)1Seq/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased body size ( J:107630 )

• by 4 days of age, mutants are smaller than wild-type littermates; this is more apparent by 3 weeks of age

homeostasis/metabolism

albuminuria ( J:107630 )

• at 3.5 and 4.5 weeks of age, mutants show excessive amounts of albumin in their urine, indicating damage to the filtration barrier

renal/urinary system

albuminuria ( J:107630 )

• at 3.5 and 4.5 weeks of age, mutants show excessive amounts of albumin in their urine, indicating damage to the filtration barrier

abnormal podocyte morphology ( J:107630 )

• by 3.5 weeks of age, loss of podocytes is observed

abnormal podocyte foot process morphology ( J:107630 )

• at E16.5, differentiated foot processes are absent in mutant embryos

fused podocyte foot processes ( J:107630 )

• in 4-day old mutants, there is complete fusion of foot processes around the capillary loops of the glomeruli

abnormal renal glomerulus morphology ( J:107630 )

• by 3.5 weeks of age, focal sclerosis and other defects are observed in the glomeruli

glomerulosclerosis ( J:107630 )

• by 3.5 weeks of age, focal sclerosis is observed in the glomeruli

renal cast ( J:107630 )

• mutants have a buildup of proteinaceous material in the kidney tubules

abnormal glomerular filtration barrier function ( J:107630 )

• damaged glomerular filtration barrier