Analysis Tools
reproductive system
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• testes of postnatal day 10 males contained fewer spermatocytes than heterozygous mice
• mutant males 21 days of age display severe degeneration and depletion of spermatocytes
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• early meiotic markers are expressed but meiosis is disrupted before completion of the first meiotic division
• germ cell intercellular bridges are not formed
• meiosis is disrupted during the first cycle of spermatogenesis
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• testes of postnatal day 10 males show early signs of Sertoli cell vacuolization due to germ cell depletion
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small testis
(
J:107660
)
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• testes from both juvenile and adult males are significantly smaller than testes of normal males
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• testes weight of 6 week old mutant males are 26% the weight of wild-type males
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endocrine/exocrine glands
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• testes of postnatal day 10 males show early signs of Sertoli cell vacuolization due to germ cell depletion
|
small testis
(
J:107660
)
|
|
• testes from both juvenile and adult males are significantly smaller than testes of normal males
|
|
|
• testes weight of 6 week old mutant males are 26% the weight of wild-type males
|
cellular
|
|
• testes of postnatal day 10 males contained fewer spermatocytes than heterozygous mice
• mutant males 21 days of age display severe degeneration and depletion of spermatocytes
|
|
|
• early meiotic markers are expressed but meiosis is disrupted before completion of the first meiotic division
• germ cell intercellular bridges are not formed
• meiosis is disrupted during the first cycle of spermatogenesis
|
