Analysis Tools
mortality/aging
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• two neonates that developed without dox being given to the mothers eventually die of megacolon
• all compound heterozygotes born to females given dox at E11.5 die of megacolon within 4 weeks of birth
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digestive/alimentary system
| N |
• when doxycycline (dox) containing water is provided to females for the entire pregnancy (thus resulting in the expression of Ednrb throughout development), compound heterozygous offspring exhibit no enteric neuron defects
• if dox is administered to pregnant mothers at or before E9.5, all compound heterozygous offspring are phenotypically normal
• some compound heterozygotes born to females given dox at E10.5 exhibit no melanocyte or enteric ganglia defects
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• two neonates that developed without dox (no expression of Ednrb) being given to the mothers eventually die of megacolon
• some compound heterozygotes born to females given dox at E10.5, have an unpigmented head and megacolon
• all compound heterozygotes born to females given dox at E11.5 die of megacolon within 4 weeks of birth
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pigmentation
| N |
• when dox-containing water is provided to females for the entire pregnancy or is administered at or before E9.5, compound heterozygous offspring exhibit no melanocyte defects
• some compound heterozygotes born to females given dox at E10.5 exhibit no melanocyte of enteric ganglia defects
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• two neonates that developed without dox being given to the mothers are almost completely white
• some compound heterozygotes born to females given dox at E10.5 exhibit unpigmented portions of the head but no megacolon, and others have an unpigmented head and megacolon
• some compound heterozygotes born to females given dox at E11.5 are amelanocytic, exhibiting the null piebald-lethal phenotype, and others are pigmented in the caudal one- to two-thirds of the body
• all compound heterozygotes born to females given dox at E12.5 or later, exhibit the piebald-lethal phenotype
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nervous system
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• compound heterozygotes born to females given dox at E11.5 exhibit no neuroblasts beyond the coecum
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integument
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• two neonates that developed without dox being given to the mothers are almost completely white
• some compound heterozygotes born to females given dox at E10.5 exhibit unpigmented portions of the head but no megacolon, and others have an unpigmented head and megacolon
• some compound heterozygotes born to females given dox at E11.5 are amelanocytic, exhibiting the null piebald-lethal phenotype, and others are pigmented in the caudal one- to two-thirds of the body
• all compound heterozygotes born to females given dox at E12.5 or later, exhibit the piebald-lethal phenotype
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