Phenotypes Associated with This Genotype

Genotype
MGI:3623950

• Allelic Composition: Gata6^tm2Msp/Gata6^tm2Msp; Tg(Tagln-cre)1Jjl/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:107814 )

• all die between E18.5 and P2

cardiovascular system

retroesophageal right subclavian artery ( J:107814 )

• 6 of 11 embryos show a retroesophageal right subclavian artery

aortic arch hypoplasia ( J:107814 )

• 7 of 11 embryos exhibit a hypoplastic aortic arch

interrupted aortic arch ( J:107814 )

• 7 of 11 embryos have an interrupted aortic arch

absent fetal ductus arteriosus ( J:107814 )

• seen in 1/11 mutant mice

persistent truncus arteriosus ( J:107814 )

• seen in 7 of 11 embryos

double outlet right ventricle ( J:107814 )

• seen in 4 of 11 embryos

perimembraneous ventricular septal defect ( J:107814 )

• all embryos exhibit a membranous ventricular septal defect

homeostasis/metabolism

cyanosis ( J:107814 )

• several newborns are cyanotic and expire shortly after birth